Artificial intelligence is generating cascading upheavals that challenge all social leaders in the new economy. The technical risks involved in deploying AI solutions are now identified and the market offers a large number of possible solutions. However, we can notice emerging new challenges, social and ethical, generated by a necessary cohabitation between AI solutions and their users. In addition to the apocalyptic scenarios announcing the end of Humanity, transhumanists stigmatize an inescapable reason to increase mankind’s skills with the capacity of machines. But recent discoveries in neuroscience point to another solution, involving the deployment of a collective brain within each company. Will the ultimate challenge therefore be managerial? In the visionary capacity of a leader who would know how to provoke an ethical symbiosis between the electronic speed of AI and the extraordinary plasticity of our biological brain? It is this exciting adventure and its exploratory solutions that certainly reveal the major challenge of neuro management.”